miR-497 suppresses angiogenesis in breast carcinoma by targeting HIF-1α
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چکیده
منابع مشابه
MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1
Hepatocellular carcinoma (HCC) is a worldwide malignance and displays marked vascular abnormalities and active metastasis. MicroRNAs (miRNAs) have been shown to play important roles in regulating tumor properties in cancer, however, whether miR-497 contributes to HCC angiogenesis or metastasis remains unclear. In this study, we found that miR-497 was significantly down-regulated in HCC tissue s...
متن کاملMiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity
A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually decreases during ageing. Mice with depletion of miR-497∼195 in endothelial cel...
متن کاملNK4 suppresses cholangiocarcinoma angiogenesis and invasion through targeting HIF-1α pathway
Cholangiocarcinoma (CCA) is a deadly biliary tract and hepatic malignancy with complicated genetics. This study aims to investigate the effect of hepatocyte growth factor (HGF) antagonist NK4 in inhibiting CCA cell hypoxic growth and invasion in vitro and in vivo. Human CCA cells stably transfected with NK4 (Hu-NK4) or control plasmid (Hu-Em) were treated with HGF under normoxia or hypoxia. The...
متن کاملTargeting Hypoxia and Angiogenesis through HIF-1α Inhibition
Hypoxia is an important phenomenon in the tumor microenvironment. Hypoxic tumors are more aggressive and resistant to anti-neoplastic treatments. HIF-1α plays a major role in the response of tumors to hypoxia, and it is mainly responsible for the “angiogenic switch”. HIF-1α contributes to tumor aggressiveness, invasiveness and resistance to radiotherapy and chemotherapy. Targeting HIF-1α is an ...
متن کاملMiR-138 suppresses expression of hypoxia-inducible factor 1α (HIF-1α) in clear cell renal cell carcinoma 786-O cells.
OBJECTIVES Hypoxia-inducible factor-1alpha (HIF-1a) is widely considered to be one of the key regulators in cancer cells. Here, we investigated a microRNA regulating expression of HIF-1a and explored its functions in clear cell renal cell carcinoma (ccRCC) cells. METHODS AND MATERIALS Western blot and reporter assays were used to assess HIF-1a as a direct target of miR-138. The effects of miR...
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ژورنال
عنوان ژورنال: Oncology Reports
سال: 2015
ISSN: 1021-335X,1791-2431
DOI: 10.3892/or.2015.4529